MovDisordV3, Main, Exploration, bibRecord, 002999

Apathy following subthalamic stimulation in Parkinson disease: A dopamine responsive symptom

Identifieur interne : 002999 ( Main/Exploration ); précédent : 002998; suivant : 002A00

Apathy following subthalamic stimulation in Parkinson disease: A dopamine responsive symptom

Auteurs : Virginie Czernecki [France] ; Michael Schüpbach [France, Suisse] ; Sadek Yaici [France] ; Richard Lévy [France] ; Eric Bardinet [France] ; Jérôme Yelnik [France] ; Bruno Dubois [France] ; Yves Agid [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-05-15.

RBID : ISTEX:ED91C023356D1D4FFF7501D9DD48101CF35B1793

Descripteurs français

Pascal (Inist)
- Apathie, Dopamine, Maladie de Parkinson, Pathologie du système nerveux.

English descriptors

KwdEn :
- Aged, Apathy, Deep Brain Stimulation (adverse effects), Dopamine, Dopamine Agonists (therapeutic use), Female, Humans, Indoles (pharmacology), Indoles (therapeutic use), Male, Middle Aged, Mood Disorders (etiology), Nervous system diseases, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson disease, Receptors, Dopamine D2 (drug effects), Receptors, Dopamine D3 (drug effects), Subthalamic Nucleus (physiopathology), apathy, dopaminergic agonist, subthalamic stimulation.
MESH :
- chemical , drug effects : Receptors, Dopamine D2, Receptors, Dopamine D3.
- chemical , pharmacology : Indoles.
- chemical , therapeutic use : Dopamine Agonists, Indoles.
- adverse effects : Deep Brain Stimulation.
- drug therapy : Parkinson Disease.
- etiology : Mood Disorders.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- psychology : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.

Abstract

To evaluate the effects of the dopamine D2‐D3 agonist ropinirole in patients who developed apathy after complete withdrawal from dopaminergic medication following successful subthalamic nucleus (STN) stimulation for advanced Parkinson disease (PD). We assessed apathy (Apathy Scale, Apathy Inventory), mood (Montgomery‐Åsberg Depression Rating Scale), cognitive functions (Mattis Dementia rating scale, frontal score, executive tests) and motor state (UPDRS‐III) in 8 PD patients treated with STN stimulation without dopaminergic treatment and who became apathetic. Assessments were made at baseline and after 6 weeks of ropinirole treatment (7.2 ± 5.9 mg/d; range 1–18 mg/d). Apathy improved with ropinirole in all but 1 patient (54 ± 24%; range 0–78%). Mood also improved (75 ± 31%; range 0–100%), but not in correlation with the change in apathy. Cognitive performance was not modified. Stimulation contacts were located within the STN in all patients except the one who remained apathetic in spite of ropinirole treatment (zona incerta). We suggest that apathy, which was compensated for by an enhancement of D2‐D3 receptor stimulation in PD patients with STN stimulation: (1) depends on a dopaminergic deficit in associativo‐limbic areas of the brain and (2) can be avoided if a dopaminergic agonist is administered postoperatively. © 2008 Movement Disorder Society

Url:

DOI: 10.1002/mds.21949

Affiliations:

Le document en format XML

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<term>Apathy</term>
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<term>Dopamine</term>
<term>Dopamine Agonists (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Indoles (pharmacology)</term>
<term>Indoles (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mood Disorders (etiology)</term>
<term>Nervous system diseases</term>
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<term>Parkinson Disease (physiopathology)</term>
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<term>Parkinson disease</term>
<term>Receptors, Dopamine D2 (drug effects)</term>
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<term>Subthalamic Nucleus (physiopathology)</term>
<term>apathy</term>
<term>dopaminergic agonist</term>
<term>subthalamic stimulation</term>
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<term>Subthalamic Nucleus</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">To evaluate the effects of the dopamine D2‐D3 agonist ropinirole in patients who developed apathy after complete withdrawal from dopaminergic medication following successful subthalamic nucleus (STN) stimulation for advanced Parkinson disease (PD). We assessed apathy (Apathy Scale, Apathy Inventory), mood (Montgomery‐Åsberg Depression Rating Scale), cognitive functions (Mattis Dementia rating scale, frontal score, executive tests) and motor state (UPDRS‐III) in 8 PD patients treated with STN stimulation without dopaminergic treatment and who became apathetic. Assessments were made at baseline and after 6 weeks of ropinirole treatment (7.2 ± 5.9 mg/d; range 1–18 mg/d). Apathy improved with ropinirole in all but 1 patient (54 ± 24%; range 0–78%). Mood also improved (75 ± 31%; range 0–100%), but not in correlation with the change in apathy. Cognitive performance was not modified. Stimulation contacts were located within the STN in all patients except the one who remained apathetic in spite of ropinirole treatment (zona incerta). We suggest that apathy, which was compensated for by an enhancement of D2‐D3 receptor stimulation in PD patients with STN stimulation: (1) depends on a dopaminergic deficit in associativo‐limbic areas of the brain and (2) can be avoided if a dopaminergic agonist is administered postoperatively. © 2008 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Apathy following subthalamic stimulation in Parkinson disease: A dopamine responsive symptom

Apathy following subthalamic stimulation in Parkinson disease: A dopamine responsive symptom

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.